哈佛大学stem cell （干细胞）实验新进展

sleepyatian

原文：（http://news.harvard.edu/gazette/story/2013/01/a-treatment-for-als/）

大意：哈佛大学医学院的杨副教授表示，虽然这11个独立研究的结果并不表示ALS是可治愈的，但是至少是给ALS治疗，病人生活质量的提高带来了一线光明！
研究者把神经干细胞注入老鼠体内，25%接受治疗的老鼠生命平均延长了1年，大约比未受治疗老鼠的延长了3-4倍。 通过干细胞的移植，虽然已损坏的细胞不能得到重生或者修复，但现存的神经元细胞的功能却可以得到保护。这一成果如果能推广到人类， 病人的生活质量和生存时间是有希望得到提高的。



Results from a meta-analysis of 11 independent amyotrophic lateral sclerosis (ALS) research studies are giving hope to the ALS community by showing, for the first time, that the fatal disease may be treatable.

“This significant research will help us better understand the mechanisms underlying motor neuron diseases,” said Yang (Ted) Teng, Harvard Medical School associate professor of surgery at the Harvard-affiliated Brigham and Women’s Hospital and one of the study’s co-lead authors. Teng is also director of the Children’s Hospital Boston and Veterans Affairs Boston Healthcare System; Sanford-Burnham Medical Research Institute; University of Massachusetts Medical School; Johns Hopkins University; State University of New York Upstate Medical University; and Columbia University.

http://news.harvard.edu/gazette/wp-content/uploads/2013/01/Yang-Ted-Teng_Co-AUTHOR.jpg

“This is not a cure for ALS. But it shows the potential that mechanisms used by neural stem cells in our study have for improving an ALS patient’s quality of life and length of life,” said Yang (Ted) Teng, Harvard Medical School associate professor of surgery and one of the principal investigators of Project ALS’ consortium project. Photo courtesy of Yang (Ted) Teng

ALS causes nerve cells in the spinal cord to die, eventually taking away a person’s ability to move or even breathe. A decade of research conducted at multiple institutions showed, however, that when neural stem cells were transplanted into multilevels of the spinal cord of a mouse model with familial ALS, disease onset and progression slowed, motor and breathing function improved, and treated mice survived three to four times longer than untreated mice.

A summary of the findings from all 11 studies was published online in December in Science Translational Medicine.

“This work sheds new light on detrimental roles played by non-neuronal cells in triggering motor neuron death, and these events should be targeted for developing more effective therapeutics to treat ALS,” Teng said.

The transplanted neural stem cells help by producing factors that preserve the health and function of the host’s remaining nerve cells. They also reduce inflammation and suppress the number of disease-causing cells in the host’s spinal cord. The neural stem cells did not replace deteriorating nerve cells in the mice with ALS.

Researchers observed improved motor performance and respiratory function in the treated mice. The neural stem cell transplant also slowed the disease’s progression. Twenty-five percent of the treated ALS mice in the study survived for one year or more — roughly three to four times longer than the untreated mice.

“This is not a cure for ALS,” said Teng, who is one of the principal investigators of Project ALS’ consortium project. “But it shows the potential that mechanisms used by neural stem cells in our study have for improving an ALS patient’s quality of life and length of life.”

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孤独浪子

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李莉

:victory:

决战到底

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重庆白云

:handshake

一线天

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走过繁华

加快速度！

感谢有你

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Rose

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优雅

UP

tkjxz

可是到临床一期二期 三期四期又是一个漫长的过程。

ydx

“以色列方面二期实验最后一名病人随访已经完成，最终统计分析结果预计12月出来，另外美国方面二期临床实验仍在继续，可能要持续到2015年中期。二期实验会对治疗的安全性和有效进行评估，其中包括对病人的功能评定和FVC功能评定。”看来最可值得期待的是以色列的疗法，其实，我对日本的”HGF“疗法一直充满期待，但”千呼万唤“就是迟迟不见结果。